{"id":1300,"date":"2025-02-26T21:58:14","date_gmt":"2025-02-26T21:58:14","guid":{"rendered":"https:\/\/content.scienceofecd.com\/transcript\/?page_id=1300"},"modified":"2025-02-26T21:58:14","modified_gmt":"2025-02-26T21:58:14","slug":"transcript-skinner-epigenetics-and-twins","status":"publish","type":"page","link":"https:\/\/content.scienceofecd.com\/transcript\/transcript-skinner-epigenetics-and-twins\/","title":{"rendered":"Transcript Skinner \u2013 epigenetics and twins"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Identical twins which have essentially the same genetics, when they\u2019re very young and born they will look alike, they\u2019ll have the same health and so forth. But when they get to be about teenagers or a little bit longer or certainly when they become adults, each one of the twins gets different environmental exposures. They may live in different places, they may have different diets, they have different exercise, their lifestyles will change a little bit. So over time then if you have 50 year old twins what\u2019s known is that the diseases that the two twins get are generally different. That\u2019s called discordant disease. The vast majority of identical twins do not have the same disease between the twins.&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If biology was totally dependent on just the DNA sequence then those twins should get the same diseases but that\u2019s not what we see. So those environmental influences, those lifestyle changes, diet and everything else will slowly change the epigenetics around the DNA such that it changes what genes are on and off and the physiology of the different tissues so that eventually you\u2019ll have a higher susceptibility for this twin to get maybe obesity and a higher susceptibility for this twin maybe getting arthritis when they get old enough. So essentially those discordant diseases is not due the DNA sequence but the environmentally changed epigenetics.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Identical twins which have essentially the same genetics, when they\u2019re very young and born they will look alike, they\u2019ll have the same health and so forth. But when they get to be about teenagers or a little bit longer or certainly when they become adults, each one of the twins gets different environmental exposures. They [&hellip;]<\/p>\n","protected":false},"author":39,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-text-only.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1300","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/content.scienceofecd.com\/transcript\/wp-json\/wp\/v2\/pages\/1300","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/content.scienceofecd.com\/transcript\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/content.scienceofecd.com\/transcript\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/content.scienceofecd.com\/transcript\/wp-json\/wp\/v2\/users\/39"}],"replies":[{"embeddable":true,"href":"https:\/\/content.scienceofecd.com\/transcript\/wp-json\/wp\/v2\/comments?post=1300"}],"version-history":[{"count":1,"href":"https:\/\/content.scienceofecd.com\/transcript\/wp-json\/wp\/v2\/pages\/1300\/revisions"}],"predecessor-version":[{"id":1301,"href":"https:\/\/content.scienceofecd.com\/transcript\/wp-json\/wp\/v2\/pages\/1300\/revisions\/1301"}],"wp:attachment":[{"href":"https:\/\/content.scienceofecd.com\/transcript\/wp-json\/wp\/v2\/media?parent=1300"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}